The incomplete germline VLR genes are flanked by hundreds of LRR
Download scientific diagram | The incomplete germline VLR genes are flanked by hundreds of LRR cassettes. The noncoding intervening sequence of germline VLR is replaced by LRR fragments that are sequentially copied from the flanking LRR cassettes. Mature complete VLR genes are assembled from either the LRRNT or LRRCT end in a stepwise fashion that is directed by short sequence homology between the donor and recipient LRR sequences. This figure was modified from [6]. from publication: Immune Related Genes Underpin the Evolution of Adaptive Immunity in Jawless Vertebrates | The study of immune related genes in lampreys and hagfish provides a unique perspective on the evolutionary genetic underpinnings of adaptive immunity and the evolution of vertebrate genomes. Separated from their jawed cousins at the stem of the vertebrate lineage, these | Vertebrates, Adaptive Immunity and Lymphocytes | ResearchGate, the professional network for scientists.
Support for three possible topologies for the hagfish/lamprey/bony
Overview & Discovery of VLRs in Lamprey - Creative Biolabs
Leucine-rich-repeat-containing variable lymphocyte receptors as modules to target plant-expressed proteins, Plant Methods
The incomplete germline VLR genes are flanked by hundreds of LRR
Assembly of the LRR-encoding gene segments.(a) Organization and
Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates
A monomer of lamprey hemoglobin generated by Pymol 0.99 (DeLano
Nathanael MCCURLEY, Research Scientist, PhD
Comparison of Ig H Chain Genes in Mouse and Shark GL mouse Ig H chain
A monomer of lamprey hemoglobin generated by Pymol 0.99 (DeLano
Sequence variability of inshore hagfish VLRs. Variability is indicated
Evolution of vertebrate adaptive immunity: Immune cells and tissues, and AID/APOBEC cytidine deaminases - Hirano - 2015 - BioEssays - Wiley Online Library
The incomplete germline VLR genes are flanked by hundreds of LRR
Variable Lymphocyte Receptors in Jawless Vertebrates: Illuminating the Origin and Early Evolution of Adaptive Immunity
The adaptive immune systems of jawless and jawed vertebrates
