The Neurobiology of Dread National Institutes of Health (NIH)

Everyone has to make decisions involving potential gains and losses. It's not always just a rational choice of what we think will bring the better outcome, though. When the outcome's delayed, the feeling we call dread can make a choice considerably more complex. A new study supported by NIH's National Institute on Drug Abuse (NIDA) shows that people who experience substantial dread about an unpleasant experience can be biologically distinguished from those who don't dread it as much. Understanding how people make choices when faced with unpleasant outcomes may yield insights into how to develop ways to counter behaviors that have harmful effects such as drug abuse.

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Neurobiological Substrates of Dread