Lamprey VLR diversity and gene rearrangement intermediates. (A) VLR

Download scientific diagram | Lamprey VLR diversity and gene rearrangement intermediates. (A) VLR scheme: signal peptide (SP), LRRNT, first LRR1, variable LRRV, end LRRVe, CP, and LRRCT (see text). Germline VLR-encoded portions of LRRNT and LRRCT are hatched. (B) Germline VLR gene rearrangement intermediates. Examples of LRR modules inserted from flanking cassettes into the germline gene: extensions of the VLR gene 5 ¶ LRRNT (F.1 þ R.1 amplicons); replacements and extensions of the VLR gene 5 ¶ LRRCT (F.1 þ R.2); and extensions of the VLR gene 3 ¶ LRRCT (F.2 þ R.3). Most insertions terminate with an incomplete LRR. Position of forward (F) and reverse (R) primers indicated; black, cDNA clones; red, genomic clones; red line in Int.36 indicates a 78-nucleotide noncoding DNA flanking the LRRVe. (C) 3D model of VLR diversity region. Positively selected solvent-exposed residues on the concave surface are represented by colored spheres: red, LRRNT; yellow, LRR1; blue, LRRV; white, LRRVe; green, b strands; magenta, a helices. from publication: Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate | Instead of the immunoglobulin-type antigen receptors of jawed vertebrates, jawless fish have variable lymphocyte receptors (VLRs), which consist of leucine-rich repeat (LRR) modules. Somatic diversification of the VLR gene is shown here to occur through a multistep assembly | Vertebrates, Lamprey and Biological Adaptation | ResearchGate, the professional network for scientists.

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